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Provide an example of the ester and ketone in the Claisen condensation.

An example of the ester and ketone in the Claisen condensation is ethyl acetate and ethyl propionate.

The Claisen condensation is a reaction between two esters or an ester and a ketone, resulting in the formation of a β-ketoester or a β-diketone. In this reaction, the carbonyl group of one molecule acts as a nucleophile and attacks the α-carbon of another molecule, forming a new carbon-carbon bond and eliminating a leaving group, usually an alkoxide ion.

One example of the Claisen condensation involves the reaction between ethyl acetate and ethyl propionate. Ethyl acetate has a carbonyl group at the α-carbon and an ethyl group at the β-carbon, while ethyl propionate has a carbonyl group at the β-carbon and an ethyl group at the α-carbon. When these two molecules react in the presence of a strong base, such as sodium ethoxide, the carbonyl group of ethyl acetate attacks the α-carbon of ethyl propionate, forming a new carbon-carbon bond and eliminating ethoxide ion. The resulting product is β-ketoester, ethyl 3-oxobutanoate.

Overall, the Claisen condensation is an important reaction in organic chemistry for the synthesis of β-ketoesters and β-diketones, which are versatile building blocks for the preparation of various organic compounds.

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