1. Lifestyle, Health and Risk1.1 Circulation, Transport and the Heart0/01.1.1 Need for Mass Transport in Animals1.1.2 Water as a Solvent for Transport1.1.3 Arteries, Veins and Capillaries1.1.4 Mammalian Heart Structure and Major Blood Vessels1.1.5 The Cardiac Cycle and Practical Heart Investigation1.2 Atherosclerosis, Blood Clotting and CVD Risk0/01.2.1 Development of Atherosclerosis1.2.2 Blood Clotting and Thrombosis in CVD1.2.3 Lifestyle and Biological Risk Factors for CVD1.2.4 Analysing Illness and Mortality Data1.2.5 Evaluating Studies of Health Risk Factors1.2.6 Perceptions of Risk in Heart Disease1.3 Energy Balance, Diet and Carbohydrates0/01.3.1 Energy Budgets and Diet Analysis1.3.2 Energy Imbalance, Weight Change and Obesity1.3.3 Monosaccharides, Disaccharides and Polysaccharides1.3.4 Carbohydrate Structure, Roles and Energy Storage1.3.5 Condensation, Glycosidic Bonds and Hydrolysis1.3.6 Vitamin C Content in Food and Drink1.4 Lipids, Cholesterol and Reducing CHD Risk0/01.4.1 Triglyceride Synthesis and Ester Bonds1.4.2 Saturated and Unsaturated Lipids1.4.3 HDL, LDL and Cholesterol Data1.4.4 Evidence Linking Cholesterol to CVD1.4.5 Reducing Coronary Heart Disease Risk1.5 Core Practical, Ethics and CVD Treatment0/01.5.1 Caffeine and Heart Rate in Daphnia1.5.2 Ethical Issues in Invertebrate Research1.5.3 Treatments for Cardiovascular Disease1. Lifestyle, Health and Risk1.1 Circulation, Transport and the Heart0/01.1.1 Need for Mass Transport in Animals1.1.2 Water as a Solvent for Transport1.1.3 Arteries, Veins and Capillaries1.1.4 Mammalian Heart Structure and Major Blood Vessels1.1.5 The Cardiac Cycle and Practical Heart Investigation1.2 Atherosclerosis, Blood Clotting and CVD Risk0/01.2.1 Development of Atherosclerosis1.2.2 Blood Clotting and Thrombosis in CVD1.2.3 Lifestyle and Biological Risk Factors for CVD1.2.4 Analysing Illness and Mortality Data1.2.5 Evaluating Studies of Health Risk Factors1.2.6 Perceptions of Risk in Heart Disease1.3 Energy Balance, Diet and Carbohydrates0/01.3.1 Energy Budgets and Diet Analysis1.3.2 Energy Imbalance, Weight Change and Obesity1.3.3 Monosaccharides, Disaccharides and Polysaccharides1.3.4 Carbohydrate Structure, Roles and Energy Storage1.3.5 Condensation, Glycosidic Bonds and Hydrolysis1.3.6 Vitamin C Content in Food and Drink1.4 Lipids, Cholesterol and Reducing CHD Risk0/01.4.1 Triglyceride Synthesis and Ester Bonds1.4.2 Saturated and Unsaturated Lipids1.4.3 HDL, LDL and Cholesterol Data1.4.4 Evidence Linking Cholesterol to CVD1.4.5 Reducing Coronary Heart Disease Risk1.5 Core Practical, Ethics and CVD Treatment0/01.5.1 Caffeine and Heart Rate in Daphnia1.5.2 Ethical Issues in Invertebrate Research1.5.3 Treatments for Cardiovascular Disease2. Genes and Health2.1 Gas Exchange Surfaces and Diffusion0/02.1.1 Properties of Effective Gas Exchange Surfaces2.1.2 Fick's Law and Rate of Diffusion2.1.3 Mammalian Lung Adaptations for Gas Exchange2.2 Cell Membranes and Membrane Models0/02.2.1 Structure and Properties of Cell Membranes2.2.2 The Fluid Mosaic Model as a Scientific Model2.2.3 Investigating Membrane Permeability2.3 Movement Across Membranes0/02.3.1 Osmosis and Free Water Molecules2.3.2 Diffusion and Facilitated Diffusion2.3.3 Active Transport and the Role of ATP2.3.4 Endocytosis and Exocytosis2.4 Nucleotides, DNA and RNA0/02.4.1 Mononucleotides and Their Components2.4.2 Bases in DNA and RNA2.4.3 Polynucleotides, DNA and RNA Structure2.4.4 Complementary Base Pairing and the DNA Double Helix2.5 Genes, the Genetic Code and Protein Synthesis0/02.5.1 Genes as Base Sequences2.5.2 The Nature of the Genetic Code2.5.3 Transcription and the DNA Template Strand2.5.4 Translation, mRNA and tRNA2.5.5 Start and Stop Codons in Protein Synthesis2.6 Amino Acids, Proteins and Enzymes0/02.6.1 Amino Acid Structure and Peptide Bonds2.6.2 Primary Structure and Protein Folding2.6.3 Globular and Fibrous Proteins2.6.4 Enzyme Action, Specificity and Activation Energy2.6.5 Intracellular and Extracellular Enzymes2.6.6 Investigating Initial Rates of Enzyme Reactions2.7 DNA Replication, Mutations and Cystic Fibrosis0/02.7.1 DNA Replication and DNA Polymerase2.7.2 Meselson and Stahl's Experiment2.7.3 Replication Errors and Mutations2.7.4 Gene Mutations and Cystic Fibrosis2.7.5 Effects of Cystic Fibrosis on Body Systems2.8 Monohybrid Inheritance and Genetic Screening0/02.8.1 Key Genetic Terms2.8.2 Monohybrid Inheritance Patterns2.8.3 Uses of Genetic Screening2.8.4 Implications of Prenatal Genetic Screening2.8.5 Social and Ethical Issues in Genetic Screening2. Genes and Health2.1 Gas Exchange Surfaces and Diffusion0/02.1.1 Properties of Effective Gas Exchange Surfaces2.1.2 Fick's Law and Rate of Diffusion2.1.3 Mammalian Lung Adaptations for Gas Exchange2.2 Cell Membranes and Membrane Models0/02.2.1 Structure and Properties of Cell Membranes2.2.2 The Fluid Mosaic Model as a Scientific Model2.2.3 Investigating Membrane Permeability2.3 Movement Across Membranes0/02.3.1 Osmosis and Free Water Molecules2.3.2 Diffusion and Facilitated Diffusion2.3.3 Active Transport and the Role of ATP2.3.4 Endocytosis and Exocytosis2.4 Nucleotides, DNA and RNA0/02.4.1 Mononucleotides and Their Components2.4.2 Bases in DNA and RNA2.4.3 Polynucleotides, DNA and RNA Structure2.4.4 Complementary Base Pairing and the DNA Double Helix2.5 Genes, the Genetic Code and Protein Synthesis0/02.5.1 Genes as Base Sequences2.5.2 The Nature of the Genetic Code2.5.3 Transcription and the DNA Template Strand2.5.4 Translation, mRNA and tRNA2.5.5 Start and Stop Codons in Protein Synthesis2.6 Amino Acids, Proteins and Enzymes0/02.6.1 Amino Acid Structure and Peptide Bonds2.6.2 Primary Structure and Protein Folding2.6.3 Globular and Fibrous Proteins2.6.4 Enzyme Action, Specificity and Activation Energy2.6.5 Intracellular and Extracellular Enzymes2.6.6 Investigating Initial Rates of Enzyme Reactions2.7 DNA Replication, Mutations and Cystic Fibrosis0/02.7.1 DNA Replication and DNA Polymerase2.7.2 Meselson and Stahl's Experiment2.7.3 Replication Errors and Mutations2.7.4 Gene Mutations and Cystic Fibrosis2.7.5 Effects of Cystic Fibrosis on Body Systems2.8 Monohybrid Inheritance and Genetic Screening0/02.8.1 Key Genetic Terms2.8.2 Monohybrid Inheritance Patterns2.8.3 Uses of Genetic Screening2.8.4 Implications of Prenatal Genetic Screening2.8.5 Social and Ethical Issues in Genetic Screening3. Voice of the GenomePremium3.1 Cell Structure and Ultrastructure0/03.1.1 Cells as the Basic Unit of Living Organisms3.1.2 Ultrastructure of Eukaryotic Cells3.1.3 Protein Transport by the rER and Golgi Apparatus3.1.4 Ultrastructure of Prokaryotic Cells3.1.5 Recognising Organelles in Electron Micrographs3.2 Reproduction, Cell Division and Genetic Variation0/03.2.1 Specialisation of Mammalian Gametes3.2.2 Fertilisation in Mammals3.2.3 Genes, Loci and Linkage3.2.4 Meiosis and Genetic Variation3.2.5 Mitosis, the Cell Cycle and Identical Daughter Cells3.2.6 Core Practical 5: Observing Mitosis in a Root Tip Squash3.3 Stem Cells, Differential Gene Expression and Organisation0/03.3.1 Stem Cells, Pluripotency and Totipotency3.3.2 Scientific Decisions About Stem Cell Therapies3.3.3 Differential Gene Expression and Protein Synthesis3.3.4 Gene Switching and the lac Operon3.3.5 Tissues, Organs and Organ Systems3.4 Genotype, Epigenetics and Variation0/03.4.1 Genotype, Environment and Phenotype3.4.2 DNA Methylation and Histone Modification3.4.3 Passing On Epigenetic Changes3.4.4 Polygenic Inheritance and Multiple Loci3.4.5 Continuous Variation and Environmental Effects3. Voice of the GenomePremium3.1 Cell Structure and Ultrastructure0/03.1.1 Cells as the Basic Unit of Living Organisms3.1.2 Ultrastructure of Eukaryotic Cells3.1.3 Protein Transport by the rER and Golgi Apparatus3.1.4 Ultrastructure of Prokaryotic Cells3.1.5 Recognising Organelles in Electron Micrographs3.2 Reproduction, Cell Division and Genetic Variation0/03.2.1 Specialisation of Mammalian Gametes3.2.2 Fertilisation in Mammals3.2.3 Genes, Loci and Linkage3.2.4 Meiosis and Genetic Variation3.2.5 Mitosis, the Cell Cycle and Identical Daughter Cells3.2.6 Core Practical 5: Observing Mitosis in a Root Tip Squash3.3 Stem Cells, Differential Gene Expression and Organisation0/03.3.1 Stem Cells, Pluripotency and Totipotency3.3.2 Scientific Decisions About Stem Cell Therapies3.3.3 Differential Gene Expression and Protein Synthesis3.3.4 Gene Switching and the lac Operon3.3.5 Tissues, Organs and Organ Systems3.4 Genotype, Epigenetics and Variation0/03.4.1 Genotype, Environment and Phenotype3.4.2 DNA Methylation and Histone Modification3.4.3 Passing On Epigenetic Changes3.4.4 Polygenic Inheritance and Multiple Loci3.4.5 Continuous Variation and Environmental Effects4. Biodiversity and Natural ResourcesPremium4.1 Biodiversity, Endemism and Human Threats0/04.1.1 The Variety of Life and Human Threats4.1.2 Biodiversity and Endemism4.1.3 Measuring Species Richness in a Habitat4.1.4 Measuring Genetic Diversity with the Heterozygosity Index4.1.5 Comparing Biodiversity Using an Index of Diversity4.2 Niches, Adaptation and Evolution0/04.2.1 The Concept of an Ecological Niche4.2.2 Behavioural, Physiological and Anatomical Adaptations4.2.3 Natural Selection and Adaptation4.2.4 Natural Selection and Evolution4.2.5 Hardy-Weinberg and Allele Frequency Change4.2.6 Reproductive Isolation and Speciation4.3 Classification and Plant Cell Ultrastructure0/04.3.1 Classification and the Species Concept4.3.2 Molecular Phylogeny and the Three Domains4.3.3 Ultrastructure of Plant Cells4.3.4 Comparing Plant and Animal Cells4.3.5 Recognising Organelles in Electron Micrographs4.4 Plant Polysaccharides and Vascular Tissues0/04.4.1 Structure and Function of Starch4.4.2 Cellulose, Hydrogen Bonds and Microfibrils4.4.3 Cellulose Microfibrils, Secondary Thickening and Plant Fibres4.4.4 Identifying Plant Tissues in Stems4.4.5 Comparing Sclerenchyma, Xylem and Phloem4.5 Plant Resources, Mineral Nutrition and Antimicrobials0/04.5.1 Water and Inorganic Ions in Plants4.5.2 Investigating Plant Mineral Deficiencies4.5.3 Testing the Tensile Strength of Plant Fibres4.5.4 Development of Drug Testing4.5.5 Bacterial Growth and Plant Antimicrobials4.5.6 Plant Products and Sustainability4.6 Conservation of Endangered Species0/04.6.1 Conserving Endangered Species and Genetic Diversity4.6.2 Zoos, Captive Breeding and Reintroduction4.6.3 Seed Banks and Plant Conservation4. Biodiversity and Natural ResourcesPremium4.1 Biodiversity, Endemism and Human Threats0/04.1.1 The Variety of Life and Human Threats4.1.2 Biodiversity and Endemism4.1.3 Measuring Species Richness in a Habitat4.1.4 Measuring Genetic Diversity with the Heterozygosity Index4.1.5 Comparing Biodiversity Using an Index of Diversity4.2 Niches, Adaptation and Evolution0/04.2.1 The Concept of an Ecological Niche4.2.2 Behavioural, Physiological and Anatomical Adaptations4.2.3 Natural Selection and Adaptation4.2.4 Natural Selection and Evolution4.2.5 Hardy-Weinberg and Allele Frequency Change4.2.6 Reproductive Isolation and Speciation4.3 Classification and Plant Cell Ultrastructure0/04.3.1 Classification and the Species Concept4.3.2 Molecular Phylogeny and the Three Domains4.3.3 Ultrastructure of Plant Cells4.3.4 Comparing Plant and Animal Cells4.3.5 Recognising Organelles in Electron Micrographs4.4 Plant Polysaccharides and Vascular Tissues0/04.4.1 Structure and Function of Starch4.4.2 Cellulose, Hydrogen Bonds and Microfibrils4.4.3 Cellulose Microfibrils, Secondary Thickening and Plant Fibres4.4.4 Identifying Plant Tissues in Stems4.4.5 Comparing Sclerenchyma, Xylem and Phloem4.5 Plant Resources, Mineral Nutrition and Antimicrobials0/04.5.1 Water and Inorganic Ions in Plants4.5.2 Investigating Plant Mineral Deficiencies4.5.3 Testing the Tensile Strength of Plant Fibres4.5.4 Development of Drug Testing4.5.5 Bacterial Growth and Plant Antimicrobials4.5.6 Plant Products and Sustainability4.6 Conservation of Endangered Species0/04.6.1 Conserving Endangered Species and Genetic Diversity4.6.2 Zoos, Captive Breeding and Reintroduction4.6.3 Seed Banks and Plant Conservation5. On the Wild SidePremium5.1 Ecosystems, Habitats and Ecological Niches0/05.1.1 Ecosystems, Communities, Populations and Habitats5.1.2 Biotic and Abiotic Factors in Habitats5.1.3 Ecological Niches, Distribution and Abundance5.1.4 Investigating Distribution and Abundance Using Quadrats and Transects5.1.5 Measuring Abiotic Factors in Ecological Fieldwork5.2 Succession and the Role of Photosynthesis in Ecosystems0/05.2.1 Stages of Ecological Succession5.2.2 The Overall Reaction of Photosynthesis5.2.3 Photosynthesis, Glucose and Energy Storage5.2.4 ATP, ADP and Energy Transfer in Cells5.3 Light-Dependent Reactions and Chloroplast Structure0/05.3.1 Chlorophyll and Electron Excitation5.3.2 Photophosphorylation and ATP Production5.3.3 Photolysis of Water and NADP Reduction5.3.4 Chloroplast Structure and Photosynthesis5.3.5 Investigating Photosynthesis Using the Hill Reaction5.4 Light-Independent Reactions and Biological Molecule Synthesis0/05.4.1 Carbon Fixation in the Calvin Cycle5.4.2 GP, GALP, RuBP and RUBISCO in Photosynthesis5.4.3 Simple Sugars and New Biological Molecules5.5 Productivity, Respiration and Energy Transfer0/05.5.1 Gross Primary Productivity, Plant Respiration and Net Primary Productivity5.5.2 Calculating Net Primary Productivity5.5.3 Efficiency of Biomass and Energy Transfers5.6 Evidence, Causes and Modelling of Climate Change0/05.6.1 Evidence for Climate Change5.6.2 Correlations, Causal Relationships and Climate Data5.6.3 Anthropogenic Climate Change and Greenhouse Gases5.6.4 Climate Models, Extrapolation and Predictions5.6.5 Limitations of Climate Change Models5.7 Climate Change Effects and Temperature-Dependent Processes0/05.7.1 Effects of Changing Rainfall Patterns and Seasonal Cycles5.7.2 Effects of Climate Change on Plant and Animal Distribution5.7.3 Climate Change, Development and Life Cycles5.7.4 Temperature and Enzyme Activity5.7.5 Investigating Temperature, Enzymes and Organism Development5.8 Evolution, Scientific Evidence and Speciation0/05.8.1 Evolution as a Change in Allele Frequency5.8.2 Scientific Validation of Evidence for Evolution5.8.3 Proteomics and Genomics as Evidence for Evolution5.8.4 Isolation, Gene Flow and Speciation5.9 Carbon Management, Conservation and Human Responsibility0/05.9.1 Scientific Conclusions and Controversial Climate Issues5.9.2 Applying the Carbon Cycle to Reduce Carbon Dioxide5.9.3 Reforestation, Sustainable Resources and Biofuels5. On the Wild SidePremium5.1 Ecosystems, Habitats and Ecological Niches0/05.1.1 Ecosystems, Communities, Populations and Habitats5.1.2 Biotic and Abiotic Factors in Habitats5.1.3 Ecological Niches, Distribution and Abundance5.1.4 Investigating Distribution and Abundance Using Quadrats and Transects5.1.5 Measuring Abiotic Factors in Ecological Fieldwork5.2 Succession and the Role of Photosynthesis in Ecosystems0/05.2.1 Stages of Ecological Succession5.2.2 The Overall Reaction of Photosynthesis5.2.3 Photosynthesis, Glucose and Energy Storage5.2.4 ATP, ADP and Energy Transfer in Cells5.3 Light-Dependent Reactions and Chloroplast Structure0/05.3.1 Chlorophyll and Electron Excitation5.3.2 Photophosphorylation and ATP Production5.3.3 Photolysis of Water and NADP Reduction5.3.4 Chloroplast Structure and Photosynthesis5.3.5 Investigating Photosynthesis Using the Hill Reaction5.4 Light-Independent Reactions and Biological Molecule Synthesis0/05.4.1 Carbon Fixation in the Calvin Cycle5.4.2 GP, GALP, RuBP and RUBISCO in Photosynthesis5.4.3 Simple Sugars and New Biological Molecules5.5 Productivity, Respiration and Energy Transfer0/05.5.1 Gross Primary Productivity, Plant Respiration and Net Primary Productivity5.5.2 Calculating Net Primary Productivity5.5.3 Efficiency of Biomass and Energy Transfers5.6 Evidence, Causes and Modelling of Climate Change0/05.6.1 Evidence for Climate Change5.6.2 Correlations, Causal Relationships and Climate Data5.6.3 Anthropogenic Climate Change and Greenhouse Gases5.6.4 Climate Models, Extrapolation and Predictions5.6.5 Limitations of Climate Change Models5.7 Climate Change Effects and Temperature-Dependent Processes0/05.7.1 Effects of Changing Rainfall Patterns and Seasonal Cycles5.7.2 Effects of Climate Change on Plant and Animal Distribution5.7.3 Climate Change, Development and Life Cycles5.7.4 Temperature and Enzyme Activity5.7.5 Investigating Temperature, Enzymes and Organism Development5.8 Evolution, Scientific Evidence and Speciation0/05.8.1 Evolution as a Change in Allele Frequency5.8.2 Scientific Validation of Evidence for Evolution5.8.3 Proteomics and Genomics as Evidence for Evolution5.8.4 Isolation, Gene Flow and Speciation5.9 Carbon Management, Conservation and Human Responsibility0/05.9.1 Scientific Conclusions and Controversial Climate Issues5.9.2 Applying the Carbon Cycle to Reduce Carbon Dioxide5.9.3 Reforestation, Sustainable Resources and Biofuels6. Immunity, Infection and ForensicsPremium6.1 Forensic Determination of Time and Identity0/06.1.1 Estimating Time of Death Using Decomposition and Succession6.1.2 Forensic Entomology and Insect Evidence6.1.3 Body Temperature and Muscle Contraction After Death6.1.4 Microorganisms, Decomposition and Carbon Recycling6.2 DNA Profiling and Molecular Identification0/06.2.1 DNA Profiling for Identification6.2.2 DNA Profiling and Genetic Relationships6.2.3 Amplifying DNA Using PCR6.2.4 Separating DNA Fragments by Gel Electrophoresis6.3 Pathogens and Infectious Disease0/06.3.1 Comparing the Structure of Bacteria and Viruses6.3.2 Tuberculosis Infection and Symptoms6.3.3 HIV Infection and Symptoms6.3.4 Routes of Pathogen Entry into the Body6.3.5 Barriers Against Infection6.4 Non-Specific and Specific Immune Responses0/06.4.1 Inflammation, Lysozyme and Interferon6.4.2 Phagocytosis and Antigen Presentation6.4.3 Antigens, Antibodies and Plasma Cells6.4.4 B Cells in the Immune Response6.4.5 T Cells in the Immune Response6.5 Immunity, Gene Expression and Pathogen Evolution0/06.5.1 Natural, Artificial, Active and Passive Immunity6.5.2 Post-Transcriptional Changes to mRNA6.5.3 Evolutionary Race Between Pathogens and Hosts6.6 Antibiotics and Hospital Acquired Infections0/06.6.1 Bacteriostatic and Bactericidal Antibiotics6.6.2 Investigating the Effect of Antibiotics on Bacteria6.6.3 Hospital Acquired Infections and Antibiotic Prescription6.6.4 Infection Prevention and Control in Hospitals6. Immunity, Infection and ForensicsPremium6.1 Forensic Determination of Time and Identity0/06.1.1 Estimating Time of Death Using Decomposition and Succession6.1.2 Forensic Entomology and Insect Evidence6.1.3 Body Temperature and Muscle Contraction After Death6.1.4 Microorganisms, Decomposition and Carbon Recycling6.2 DNA Profiling and Molecular Identification0/06.2.1 DNA Profiling for Identification6.2.2 DNA Profiling and Genetic Relationships6.2.3 Amplifying DNA Using PCR6.2.4 Separating DNA Fragments by Gel Electrophoresis6.3 Pathogens and Infectious Disease0/06.3.1 Comparing the Structure of Bacteria and Viruses6.3.2 Tuberculosis Infection and Symptoms6.3.3 HIV Infection and Symptoms6.3.4 Routes of Pathogen Entry into the Body6.3.5 Barriers Against Infection6.4 Non-Specific and Specific Immune Responses0/06.4.1 Inflammation, Lysozyme and Interferon6.4.2 Phagocytosis and Antigen Presentation6.4.3 Antigens, Antibodies and Plasma Cells6.4.4 B Cells in the Immune Response6.4.5 T Cells in the Immune Response6.5 Immunity, Gene Expression and Pathogen Evolution0/06.5.1 Natural, Artificial, Active and Passive Immunity6.5.2 Post-Transcriptional Changes to mRNA6.5.3 Evolutionary Race Between Pathogens and Hosts6.6 Antibiotics and Hospital Acquired Infections0/06.6.1 Bacteriostatic and Bactericidal Antibiotics6.6.2 Investigating the Effect of Antibiotics on Bacteria6.6.3 Hospital Acquired Infections and Antibiotic Prescription6.6.4 Infection Prevention and Control in Hospitals7. Run for your LifePremium7.1 Movement by the Musculoskeletal System0/07.1.1 Roles of Muscles, Tendons, Bones and Ligaments in Movement7.1.2 Antagonistic Muscle Pairs7.1.3 Flexors and Extensors7.1.4 Skeletal Muscle Contraction and the Sliding Filament Theory7.1.5 Regulatory Proteins and Calcium Ions in Muscle Contraction7.1.6 ATP, ATPase and Cross-Bridge Cycling7.2 Respiration and ATP Production0/07.2.1 The Overall Reaction of Aerobic Respiration7.2.2 Respiration as an Enzyme-Controlled Process7.2.3 Glycolysis in Aerobic and Anaerobic Respiration7.2.4 Anaerobic Respiration and Lactate Production7.2.5 The Link Reaction and Krebs Cycle7.2.6 Mitochondria, Oxidative Phosphorylation and Chemiosmosis7.3 Respiration Rate and Lactate Recovery0/07.3.1 The Fate of Lactate After Anaerobic Respiration7.3.2 Investigating Rate of Respiration7.4 Cardiac Function and Exercise0/07.4.1 Myogenic Cardiac Muscle7.4.2 Electrical Coordination of the Heartbeat7.4.3 ECGs and Heart Condition Diagnosis7.4.4 Calculating Cardiac Output7.4.5 Ventilation and Cardiac Output During Exercise7.4.6 Control of Heart Rate and Ventilation Rate7.5 Spirometry, Muscle Fibres and Feedback0/07.5.1 Interpreting Spirometer Traces During Exercise7.5.2 Structure of a Muscle Fibre7.5.3 Fast and Slow Twitch Muscle Fibres7.5.4 Negative and Positive Feedback Control7.5.5 Negative Feedback and Narrow Limits7.6 Homeostasis, Exercise and Sport0/07.6.1 Homeostasis During Exercise7.6.2 Hypothalamus and Thermoregulation7.6.3 Interpreting Data on Too Much and Too Little Exercise7.6.4 Medical Technology and Participation in Sport7.6.5 Ethics of Performance-Enhancing Substances7.6.6 Gene Switching by Transcription Factors and Hormones7. Run for your LifePremium7.1 Movement by the Musculoskeletal System0/07.1.1 Roles of Muscles, Tendons, Bones and Ligaments in Movement7.1.2 Antagonistic Muscle Pairs7.1.3 Flexors and Extensors7.1.4 Skeletal Muscle Contraction and the Sliding Filament Theory7.1.5 Regulatory Proteins and Calcium Ions in Muscle Contraction7.1.6 ATP, ATPase and Cross-Bridge Cycling7.2 Respiration and ATP Production0/07.2.1 The Overall Reaction of Aerobic Respiration7.2.2 Respiration as an Enzyme-Controlled Process7.2.3 Glycolysis in Aerobic and Anaerobic Respiration7.2.4 Anaerobic Respiration and Lactate Production7.2.5 The Link Reaction and Krebs Cycle7.2.6 Mitochondria, Oxidative Phosphorylation and Chemiosmosis7.3 Respiration Rate and Lactate Recovery0/07.3.1 The Fate of Lactate After Anaerobic Respiration7.3.2 Investigating Rate of Respiration7.4 Cardiac Function and Exercise0/07.4.1 Myogenic Cardiac Muscle7.4.2 Electrical Coordination of the Heartbeat7.4.3 ECGs and Heart Condition Diagnosis7.4.4 Calculating Cardiac Output7.4.5 Ventilation and Cardiac Output During Exercise7.4.6 Control of Heart Rate and Ventilation Rate7.5 Spirometry, Muscle Fibres and Feedback0/07.5.1 Interpreting Spirometer Traces During Exercise7.5.2 Structure of a Muscle Fibre7.5.3 Fast and Slow Twitch Muscle Fibres7.5.4 Negative and Positive Feedback Control7.5.5 Negative Feedback and Narrow Limits7.6 Homeostasis, Exercise and Sport0/07.6.1 Homeostasis During Exercise7.6.2 Hypothalamus and Thermoregulation7.6.3 Interpreting Data on Too Much and Too Little Exercise7.6.4 Medical Technology and Participation in Sport7.6.5 Ethics of Performance-Enhancing Substances7.6.6 Gene Switching by Transcription Factors and Hormones8. Grey MatterPremium8.1 Neurones and Nervous Responses0/08.1.1 Structure and Function of Sensory, Relay and Motor Neurones8.1.2 Schwann Cells, Myelination and Axon Insulation8.1.3 Stimulus-Response Pathways and Effectors8.1.4 Pupil Dilation and Constriction as a Nervous Response8.2 Nerve Impulses and Synapses0/08.2.1 Action Potentials and Ion Movement Along Axons8.2.2 Saltatory Conduction in Myelinated Axons8.2.3 Synapse Structure and Nerve Impulse Transmission8.2.4 Neurotransmitters and Acetylcholine at Synapses8.3 Detecting Stimuli and Vision0/08.3.1 Rod Cells in the Mammalian Retina8.3.2 Rhodopsin, Opsin and Retinal in Photoreception8.3.3 Sodium Ions, Cation Channels and Rod Cell Hyperpolarisation8.3.4 Critical Periods and Development of Visual Capacity8.4 Plant Responses to Environmental Cues0/08.4.1 Phytochrome and Plant Responses to Light8.4.2 IAA and Plant Growth Responses8.5 Coordination and the Human Brain0/08.5.1 Nervous and Hormonal Coordination in Animals8.5.2 Cerebral Hemispheres and Higher Brain Functions8.5.3 Hypothalamus, Cerebellum and Medulla Oblongata8.5.4 MRI and CT Scans in Brain Diagnosis8.5.5 fMRI and PET Scans in Brain Function Studies8.6 Brain Development, Learning and Research Ethics0/08.6.1 Animal Models in Brain Development Research8.6.2 Hubel and Wiesel’s Experiments with Monkeys and Kittens8.6.3 Ethical Standpoints on Animals in Medical Research8.6.4 Habituation as a Form of Learning8.6.5 Investigating Habituation to a Stimulus8.6.6 Nature, Nurture and Brain Development Evidence8.7 Brain Chemicals, Drugs and Personalised Medicine0/08.7.1 Dopamine, Parkinson’s Disease and Brain Chemical Imbalance8.7.2 Serotonin, Depression and Drug Development8.7.3 Drugs and Synaptic Transmission8.7.4 L-Dopa and Parkinson’s Disease Treatment8.7.5 MDMA, Ecstasy and Synaptic Transmission8.7.6 Genome Sequencing and Personalised Medicine8.8 Genetic Modification and Drug Production0/08.8.1 Producing Drugs Using Genetically Modified Microorganisms8.8.2 Producing Drugs Using Genetically Modified Plants and Animals8.8.3 Benefits of Using Genetically Modified Organisms8.8.4 Risks of Using Genetically Modified Organisms8. Grey MatterPremium8.1 Neurones and Nervous Responses0/08.1.1 Structure and Function of Sensory, Relay and Motor Neurones8.1.2 Schwann Cells, Myelination and Axon Insulation8.1.3 Stimulus-Response Pathways and Effectors8.1.4 Pupil Dilation and Constriction as a Nervous Response8.2 Nerve Impulses and Synapses0/08.2.1 Action Potentials and Ion Movement Along Axons8.2.2 Saltatory Conduction in Myelinated Axons8.2.3 Synapse Structure and Nerve Impulse Transmission8.2.4 Neurotransmitters and Acetylcholine at Synapses8.3 Detecting Stimuli and Vision0/08.3.1 Rod Cells in the Mammalian Retina8.3.2 Rhodopsin, Opsin and Retinal in Photoreception8.3.3 Sodium Ions, Cation Channels and Rod Cell Hyperpolarisation8.3.4 Critical Periods and Development of Visual Capacity8.4 Plant Responses to Environmental Cues0/08.4.1 Phytochrome and Plant Responses to Light8.4.2 IAA and Plant Growth Responses8.5 Coordination and the Human Brain0/08.5.1 Nervous and Hormonal Coordination in Animals8.5.2 Cerebral Hemispheres and Higher Brain Functions8.5.3 Hypothalamus, Cerebellum and Medulla Oblongata8.5.4 MRI and CT Scans in Brain Diagnosis8.5.5 fMRI and PET Scans in Brain Function Studies8.6 Brain Development, Learning and Research Ethics0/08.6.1 Animal Models in Brain Development Research8.6.2 Hubel and Wiesel’s Experiments with Monkeys and Kittens8.6.3 Ethical Standpoints on Animals in Medical Research8.6.4 Habituation as a Form of Learning8.6.5 Investigating Habituation to a Stimulus8.6.6 Nature, Nurture and Brain Development Evidence8.7 Brain Chemicals, Drugs and Personalised Medicine0/08.7.1 Dopamine, Parkinson’s Disease and Brain Chemical Imbalance8.7.2 Serotonin, Depression and Drug Development8.7.3 Drugs and Synaptic Transmission8.7.4 L-Dopa and Parkinson’s Disease Treatment8.7.5 MDMA, Ecstasy and Synaptic Transmission8.7.6 Genome Sequencing and Personalised Medicine8.8 Genetic Modification and Drug Production0/08.8.1 Producing Drugs Using Genetically Modified Microorganisms8.8.2 Producing Drugs Using Genetically Modified Plants and Animals8.8.3 Benefits of Using Genetically Modified Organisms8.8.4 Risks of Using Genetically Modified Organisms