Polymorphism allows objects to be treated as instances of their parent class rather than their actual class. This affects the construction and interaction of related objects by enabling a single method to operate on objects of different classes. For example, if a `PaymentProcessor` class has a method `processPayment` that takes a `Payment` object, polymorphism allows for instances of any subclass of `Payment`, like `CreditCardPayment` or `PaypalPayment`, to be passed to this method. This enables the construction of flexible systems where related objects can be interchanged and managed under a common interface, greatly simplifying the management of object relationships and interactions.

Encapsulation strengthens relationships between objects by controlling the access to and from an object's data and behaviour. This concept promotes the idea of 'information hiding' which means that the internal representation of an object is hidden from the outside. In doing so, objects do not need to reveal their implementation details to other objects they interact with, only their interfaces. This allows objects to be changed internally without affecting other objects that use them, making the relationships more flexible and maintainable. For instance, a `BankAccount` object can change the way it calculates interest internally without the `Customer` object, which holds a reference to the `BankAccount`, needing to know any of the implementation details.

Access modifiers are keywords in object-oriented languages that set the accessibility of classes, methods, and other members. They are essential for regulating the relationships between objects as they determine how one object can access another's data and methods. For instance, the `public` access modifier allows members to be accessed from any other class, which can be useful for methods that are intended to be called across different objects. The `private` modifier restricts access to the class itself, which is important for encapsulating the internal workings of the object and only exposing what is necessary for interaction. The `protected` modifier allows access within the same class and its subclasses, facilitating inheritance relationships. Access modifiers are thus key to building robust object-oriented designs that properly control how objects are constructed and interact.

Method overloading is the process of defining multiple methods with the same name but different parameter lists within the same class. Its significance in constructing related objects is that it provides flexibility in how objects interact with each other. For example, in a class `Database`, one could overload the `addRecord` method to accept different types of objects, such as `Employee`, `Department`, or `Project`. This allows for a variety of objects to be related to the database in different ways, depending on the information they carry. It also contributes to cleaner and more intuitive code, as the method's functionality can be tailored to the type of object it is dealing with, making the relationships between objects clearer and more robust.

Constructors are special methods in a class that are called when a new object is created. They play a crucial role in constructing related objects as they initialise the new object's state with default or provided values. For instance, in a class `Person`, a constructor might initialise the person's `name` and `age` attributes. When creating related objects, constructors can also set up relationships. For example, a `Person` object could be passed to a `Job` object's constructor to link the person with a specific role, establishing a relationship between these two objects. This is essential in constructing an ecosystem of interrelated objects where each object is correctly initialised to interact with others from the moment it is created.